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Will CBD have the same affect on everyone?

Will CBD have the same affect on everyone?


For the wonderfully curious amongst our loyal CBD family, here’s a little information on why CBD can affect everyone differently…

Rafael Mechoulam, known as the ‘Father of THC’, isolated THC and elucidated the entire cannabidiol structure. Shortly after this discovery, Rafael was curious about how the THC molecule would affect different people, so he came up with a little plan to test it out on his friends. Thus, one evening he invited over a few of his friends for some ‘cake’, which little did they know, was laced with 10mg of pure THC. A few of his friends felt ‘strange, in a different world,’ while some couldn’t stop talking or giggling. While the scientist now understood that cannabis compounds, do, in fact, cause different reactions, it wasn’t until years later that we would figure out why.

Here’s a little overview as to why all cannabis (marijuana or hemp derived) products affect people differently...



About 20% of the population has good endocannabinoid genetics. These people were born with a genetic mutation that increases the level of endocannabinoids and levels of anandamide (the so-called bliss molecule) naturally occurring in their system. As a whole, the endocannabinoid system is partially responsible for regulating sleep, appetite, mood, motor control, immune function, pleasure, pain, reproduction and fertility, memory and temperature regulation. When someone consumes cannabis, the cannabinoids, like THC and CBD, replace the naturally occurring endocannabinoids in your body. Thus, if you are among the lucky few that have this genetic mutation, you are most likely less inclined to feel the effects of CBD because your body already naturally produces a similar result.


Men vs. Women

Cannabidiol products affect males and females differently. Research shows that oestrogen makes women more sensitive to cannabis. For example, in the USA, Washington State University found that women are impacted more by THC a day or two before ovulation, because of the peak in oestrogen levels.


Unique Biochemistry

Biochemistry, the study of chemical substances and vital processes occurring in living organisms is yet another explanation as to why people react differently to CBD products. No two individuals have the exact biochemistry makeup, which affects the way substances metabolise throughout our system. The health of one’s endocannabinoid system plays a significant role in this. As previously mentioned, the human body naturally produces endocannabinoids. Things like diet, stress, and overall lifestyle influences endocannabinoid levels. When consuming cannabis products, you are increasing endocannabinoid levels. For individuals who have deprived levels, cannabis consumption will most likely produce a favourable experience, whereas someone with healthy endocannabinoid levels might not “feel” the effects of CBD or other marijuana products in quite the same way.


Overall Health

Someone who is using cannabis products to treat symptoms for a disease or disorder is going to have a very different experience than someone using cannabis recreationally. When someone is fighting off an ailment or illness, that individual’s biochemistry and endocannabinoid levels are altered. Thus, when someone with Parkinson’s disease uses a product like CBD oil, the outcome may be feeling “normal” because endocannabinoid levels are replenished. The average person, on the other hand, may use the same product and feel nothing at all or very different effects.



It is relatively well-known that over time and continued use, one will most likely build a tolerance to THC. Yet, in one study conducted in 2011, findings suggest that one may not build a tolerance to CBD. However, more research needs to be done to prove this theory.


The Takeaway

There are many factors which impact upon a person’s experience of using CBD. Don’t be tempted to compare your personal results of using CBD with anyone else’s, as the chances are, your starting position and/or end goal will be entirely different. Get to know how YOU respond to CBD by starting with small doses and increasing the amount slowly and gradually. It’s advisable to log your findings in a diary so you can refer back to it whenever needed. There are many different CBD products to choose from, you will need to find the right one to suit you and your lifestyle. Why not take a look at our “CBD Product Types” blog for more information on the wide range of products available. Or alternatively, head straight over to CBD Porter’s online ‘shop’ now to browse the range of high quality CBD products we have for you to try. What are you waiting for?

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